A study published on Oncotarget, a leading medical journal, showed the challenges of AML treatment in the elderly. While it showed that there was a significant difference between the people who got AML treatment and who were not, the physicians found to be reluctant to apply an aggressive AML treatment regime for the patients. There are multiple web-based programs and scoring systems to produce accurate CR and TRM rates that help the physicians in the decision-making process, especially in aggressive therapy.
Though there are improved CR rates, the elderly AML patients show a shorter survival rate of less than a year. Almost 20% of those achieve CR do not show long-survival and stands at an average of three years. Allogeneic hematopoietic cell transplantation or alloHCT provides nearly 40% survival at two years in selected patients. The research also highlights the poor performance status and higher comorbidities that create more negative impacts than age. The short duration in the case of CR asks that leukemia and transplant physicians coordinate after diagnosis to jump quickly to alloHCT. It is essential for bridging post-remission therapy and selecting the right individual for transplant.
Another study published on Oncotarget conducted by University of Rochester Medical Center showcased that electronic cigarettes can damage teeth and gums similar to conventional cigarettes. The study was led by Irfan Rahman, a professor of Environmental Medicine, showed that it has damaging effects on oral health. While E-cigarettes got popular as it perceived as safe, the study says that it causes oral cell damages that lead to different oral diseases. It is due to the inflammatory proteins released while e-cigarettes are burned.
Rahman further explained that it is the extent of the usage of E-cigarettes by a person determines the detrimental effects on him. The study researched on the non-smoker gum with vapors of e-cigarettes and found that the flavoring chemicals are causing damages of cells in the mouth. He also added that people often do not notice the presence of nicotine in E-cigarettes that can cause gum disease. However, Rahman further added that more researches and comparative studies based on long-term results are needed to provide detailed health issues from the E-cigarettes.